徐沙

江南大学国家工程实验室副教授

徐沙，女，博士，毕业于江南大学，江南大学国家工程实验室副教授。

人物经历

2002.9 – 2006.6 南京农业大学食品科技学院本科

2006.9 – 2011.6 江南大学生物工程学院硕博连读

2012.1–2012.2日本产业综合研究所(AIST) 访问学者

2013.11–2014.2 日本产业综合研究所(AIST) 访问学者

2016.8 – 2017.8 美国康奈尔大学访问学者

2011.8-2015.10 江南大学生物工程学院校聘副教授

2015.10-至今江南大学国家工程实验室副教授

主讲课程

担代谢途径工程、发酵工程原理与技术课程。

发表论文

1.Sha Xu, Qin Wang, Weizhu Zeng, Youran Li, Guiyang Shi, Jingwen Zhou*. Construction of a heat-inducibleEscherichia coli strain for efficient de novo biosynthesis of L-tyrosine, Process Biochem, 2020, 92: 85-92.

2. Sha Xu, Yu Zhang, Youran Li, Xiaole Xia, Jingwen Zhou*, Guiyang Shi*. Production of L-tyrosine usingtyrosine phenol-lyase by whole cell biotransformation approach. Enzyme Microb. Tech. 2019, 131, 109430

3. Yongkun Lv, Sha Xu, Yunbin Lyu, Shenghu Zhou, Guocheng Du, Jian Chen, Jingwen Zhou*. Engineeringenzymatic cascades for the efficient biotransformation of eugenol and taxifolin to silybin and isosilybin. GreenChem. 2019, 21(7):1660-1667.

4. Wang Panpan, Zeng Weizhu, Xu Sha, Du Guocheng, Zhou Jingwen*, Chen Jian*. Current challenges facing onestep production of l-ascorbic acid. Biotechnol Adv. 2018, 36(7): 1882-1899.

5. Huijie Zhang, Ting Yan, Sha Xu, Shini Feng, Dandi Huang, Morihisa Fujita, Xiaodong Gao*. Graphene oxidechitosan nanocomposites for intracellular delivery of immunostimulatory CpG oligodeoxynucleotides. Mater SciEng C Mater Biol Appl. 2017, 73:144-151.

6. Weizhu Zeng, Hailin Zhang, Sha Xu, Fang Fang, Jingwen Zhou*. Biosynthesis of keto acids by fed-batch cultureof Yarrowia lipolytica WSH-Z06. Bioresour Technol. 2017, 243:1037-1043.

7. Sha Xu, Geyuan Zhang, Huijie Zhang, Toshihiko Kitajima, Hideki Nakanishi, Xiaodong Gao*. Effects of Rho1, asmall GTPase on the production of recombinant glycoproteins in Saccharomyces cerevisiae. Microb Cell Fact. 2016,15 (1):179.

8. Shengtao Li, Ning Wang, Sha Xu, Jian Yin, Hideki Nakanishi, Neta Dean, Xiaodong Gao*. Quantitative study ofyeast Alg1 beta-1,4 mannosyltransferase activity, a key enzyme involved in protein N-glycosylation. BiochimBiophys Acta 1861. 2016 (1 Pt A):2934-2941.

9. Yu Deng, Mingxue Sun, Sha Xu, Jingwen Zhou*. Enhanced (S)-linalool production by fusion expression offarnesyl diphosphate synthase and linalool synthase in Saccharomyces cerevisiae. J Appl Microbiol. 2016,doi:10.1111/jam.13105.

10. Jingwen Zhou*, Kui Wang, Sha Xu, Junjun Wu, Peiran Liu, Guocheng Du, Jianghua Li*, Jian Chen.Identification of membrane proteins associated with phenylpropanoids tolerance and transport in Escherichia coliBL21. J Proteomics. 2015, 113: 15-28.

11. Sha Xu, Xiaobei Wang, Guocheng Du, Jingwen Zhou*, Jian Chen. Enhanced production of L-sorbose from Dsorbitol by improving the mRNA abundance of sorbitol dehydrogenase in Gluconobacter oxydans WSH-003.Microb Cell Fact. 2014, 13:146.

12. Sha Xu, Yaqiong Guo, Guocheng Du, Jingwen Zhou*, Jian Chen. Self-cloning significantly enhances theproduction of catalase in Bacillus subtilis WSHDZ-01. Appl Biochem Biotechnol. 2014, 173(8): 2152-62.

13. Sha Xu, Zhengxiong Zhou, Zhaozhe Hua, Guocheng Du, Jingwen Zhou*, Jian Chen. Efficient transformation ofRhizopus delemar by electroporation of germinated spores. J Microbiol Meth. 2014. 103: 58-63.

14. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen* Arginine: a novel compatible solute to protect Candida glabrataagainst hyperosmotic stress. Proc Biochem. 2011, 44(6): 1230-1235.

15. Yi Qin, Liming Liu, Changhao Li, Sha Xu, and Jian Chen*. Accelerating glycolytic flux of Torulopsis glabrataCCTCC M202019 at high oxiodreduction potential created using potassium ferricyanide. Biotechnol Prog, 2010,26(6): 1551-1557.

16. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Water-forming NADH oxidaseprotectsTorulopsisglabrataagainst hyperosmotic stress. Yeast. 2010, 27(4): 207-216.

17. Sha Xu, Jingwen Zhou, Liming Liu*, Jian Chen*. Proline enhances Torulopsis glabrata growthduringhyperosmotic stress. Biotechnol Bioproc Eng. 2010, 15(2): 285-292.

18. 焦亭亭, 周景文, 徐沙*. 柚皮素合成关键基因表达水平对目标产物积累水平的量化影响. 生物工程学报.2019, 35(7): 1256-1265.

19. 董宁远, 张阁元, 徐沙, 高晓冬*. 来源于胞曲霉的α-1,2-甘露糖苷酶在酿酒酵母Δalg3Δoch1Δmnn1菌株中的定位表达. 食品与发酵工业. 2016, 42 (6):1-6.

20. 张阁元, 徐沙, 高晓冬*, 中西秀树. 酿酒酵母糖基化缺陷型菌株中ALG6基因的过量表达. 食品与发酵工业.2015, 41 (5):1-7.

21. 贺铁凡, 徐沙, 张阁元, 中西秀树, 高晓冬*. 重构酿酒酵母N-糖基化途径生产人源化糖蛋白. 微生物学报.2014, 54 (5):509-516.

22. 徐沙, 中西秀树, 高晓冬*. 糖蛋白药物表达系统糖基化研究进展. 微生物学报. 2013, 53 (3):221-229

专利成果

1. 堵国成, 徐沙, 刘立明, 陈坚. 一种添加脯氨酸促进丙酮酸过量积累的方法. 公开号：101225410.

2. 陈坚, 徐沙, 刘立明, 堵国成. 一种提高光滑球拟酵母抵御高渗透压胁迫的方法. 公开号：101591670

科研项目

1. 国家自然基金青年项目“超糖基化缺陷型酿酒酵母生产人源化糖蛋白N-聚糖位点占有率定向调控” (21406087), 主持

2. 江南大学自主科研计划项目基金“重组酿酒酵母产人促红细胞生成素糖基化机制的研究”，(JUSRP211A25), 主持

3. 工业生物技术教育部重点实验室开放课题“Alg1结构与膜结合性质的研究”(KLIB-KF201106),